Evaluation of anticancer potential of Terminalia chebula Fruits against Ehrlich Ascites Carcinoma induced cancer in mice

This study was designed to determine the in vivo and in vitro anticancer potential of the ethanolic extract of Terminalia chebula (ETC) fruits against Ehrlich Ascites Carcinoma (EAC) induced cancer in swiss albino mice. The anticancer activity was assessed using in vitro cytotoxicity, mean survival time, tumor volume and hematological studies. The reliable criteria for evaluating the potential of any anticancer agent is the prolongation of lifespan of the animal and decrease in WBC count of blood.The high dose of ETC (200 mg/kg, orally) significantly reduced the tumor growth which was demonstrated by increased lifespan of the mice and restoration of hematological parameters. ETC was also found to be cytotoxic in the in vitro parameter which shows that ETC possesses significant anticancer potential.